She Doesn’t Crave Your Time and Attention Anymore:
Almost every time she wanted to do something or go some where, she always wanted you to come along but suddenly that has stopped. She just doesn’t seem to need your company anymore and now spending time with you seems to be perfunctory on her part. It now seems she would rather do things on her own than with you.
Sure, she might just need some time to herself but if she has suddenly become so much more independent than she usually is, you need to look out. She might be cheating.
Her Friends Seem To Be Avoiding You:
They may know something you don’t and not want to be the ones to tell you. Or maybe, they really don’t know either. She might be acting really strange and causing them to have suspicions. They, in turn, might want to be around so you don’t pick on their confusion or suspicions about her sudden change in behaviour. Generally, sudden dodgy behaviour from the friends (or family) of your wife could be a sign that she’s cheating.
All these signs are not certain signs that your wife is cheating, so don’t jump the gun. If you have suspicions, examine yourself first: it may just be your insecurities. But if the uneasiness persists, try to find out and sometimes you just may need to have an open confrontation.